Officers are becoming increasingly concerned for 15-year-old Layton Bowman from Blurton, Stoke-on-Trent.
Layton was reported missing from his home address on 18 August.
He is described as white, around 5 foot 8 inches in height, of slim to medium build with light brown hair.
He is believed to be wearing a dark-coloured jacket with a grey hooded sweatshirt underneath, possibly with the hood up.
Layton has connections in Weston Coyney and the Macclesfield area of Cheshire.
Anyone who has seen Layton or anyone with information about his whereabouts is asked to contact Staffordshire Police on Facebook, Twitter, or call 101, quoting incident number 759 of 18 August